منابع مشابه
Immunological Maturation
Immunological maturation, the gradual increase in affinity for antigen of serum antibody with time after immunization, has been postulated to result from a competition among precursors of antibody-forming cells for available antigen (1, 2). Thus, as the antigen concentration in the cellular environment falls, only those cells with antigen-binding receptors of sufficiently high avidity to captur...
متن کاملRole of Macrophages in Immunological Maturation
1. Transplantation of peritoneal macrophages from thioglycollate-stimulated adult C3H donor mice, into 3-day-old C3H mice results in an enhanced antibody response to simultaneously injected SRBC. The increase in immuno-competence is even more pronounced when 1-day-old C3H mice are pretreated with adult macrophages and sensitized 3 days later with SRBC. Nonviable macrophages or nonviable spleen ...
متن کاملTargeting antigens to CD180 rapidly induces antigen-specific IgG, affinity maturation, and immunological memory
Antigen (Ag) targeting is an efficient way to induce immune responses. Ag is usually coupled to an antibody (Ab) specific for a receptor expressed on dendritic cells (DCs), and then the Ag-anti-receptor is inoculated with an adjuvant. Here we report that targeting Ag to a receptor expressed on both B cells and DCs, the TLR orphan receptor CD180, in the absence of adjuvant rapidly induced IgG re...
متن کاملLoss of the transferrin receptor during the maturation of sheep reticulocytes in vitro. An immunological approach.
Sheep reticulocyte-specific antiserum absorbed with mature sheep red cells has been used to isolate and identify reticulocyte-specific plasma-membrane proteins and to monitor their loss during incubation in vitro. Specific precipitation of labelled plasma-membrane proteins is obtained when detergent-solubilized extracts of 125I-labelled reticulocyte plasma membranes are incubated with this anti...
متن کاملEffect of Friend leukemia virus and Rowson-Parr virus on immunological maturation of mice.
The effect of neonatal infection with Friend virus (FV) and Rowson-Parr virus (RPV) on the maturation of the capacity to respond to sheep red cells, as measured by the numbers of hemolytic plaque-forming cells in the spleen, was investigated in BALB/c mice. Both viruses affected immunological maturation but there were significant differences between their effects. The development with age of th...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1973
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.137.1.201